Scratching the lining of the womb before conceiving a baby may double the chances of a successful birth, a new study has claimed.
There is a much disputed claim that "injury" to the lining of the uterus - whether inadvertent or deliberate - increases the chance of embryo implantation and thus the chance of pregnancy in certain groups of women having In vitro fertilisation (IVF), researchers said.
The "injury" has usually been performed as a biopsy from the womb lining (endometrium), whose action is believed to cause a favourable inflammation ("scratch") within the endometrium thereby making it more receptive to an implanting embryo. Indeed, the success of more complex uterine surgery in some studies has even been attributed to the scratch and not to the surgery itself. Now, researchers have reviewed randomised controlled trials evaluating endometrial scratching in women planning to have intrauterine insemination (IUI) or attempting to conceive spontaneously (with or without ovulation induction).
It suggests that endometrial scratching may well be beneficial in couples trying to conceive naturally or with IUI, although "the quality of the available evidence is low," said Sarah Lensen from the Department of Obstetrics and Gynaecology, University of Auckland in New Zealand.
Eight eligible trials with a total of 1,180 women were included in the review, in which endometrial scratching was compared to no intervention or a mock intervention.
The primary outcomes were live birth/ongoing pregnancy and pain from the intervention.
Following analysis, endometrial scratching appeared to increase the chance of clinical pregnancy and live birth compared to no procedure or a placebo procedure.
The difference in outcome was statistically significant and appeared to roughly double the chance of live birth compared to no intervention (relative risk 2.22).
Lensen explained that endometrial scratching would increase the normal chance of a live birth or ongoing pregnancy from 9 per cent over a set period of time to somewhere between 14 and 28 per cent.
However, "the results must be treated with caution," said Lensen.
There was no evidence that endometrial scratching has any effect on miscarriage, ectopic pregnancy, or multiple pregnancy.
Lensen described endometrial scratching as "a cheap and simple procedure" which can be conducted without analgesia during a short clinic visit; it does, however, require an internal examination which is associated with pain and discomfort.
Courtesy – Deccan Herald