Drinking three to five cups of coffee a day may provide protection against age-related cognitive decline and other neurodegenerative diseases such as Alzheimer's and Parkinson's, a new report claims.

The report by the Institute for Scientific Information on Coffee (ISIC), a not-for-profit organisation devoted to the study and disclosure of science related to coffee and health, highlights the potential role of coffee consumption in reducing the risk of cognitive decline.

The report concludes that a moderate intake of coffee (three to five cups per day) may provide protection against age-related cognitive decline and other neurodegenerative diseases such as Alzheimer's and Parkinson's.

"Moderate coffee consumption could play a significant role in reducing cognitive decline which would impact health outcomes and health-care spending across Europe," said Rodrigo A Cunha, Professor at the University of Coimbra in Portugal.

Understanding and communicating diet and lifestyle factors that may limit age-related cognitive decline will help to improve the quality of life, the report said.

According to the report, research published this year suggests that moderate coffee consumption can reduce the risk of developing Alzheimer's by up to 27 per cent.

Research has suggested that it is regular, long-term coffee drinking that is key to helping to reduce the risk of Alzheimer's Disease, the report said.

The association between coffee consumption and cognitive decline is illustrated by a 'U-shaped' pattern in recent meta-analyses, with the greatest protection seen at an intake of about three to five cups of coffee per day.

Although the precise mechanisms of action behind the suggested association between coffee and age-related cognitive decline are unknown, caffeine is likely to be involved.

There are many other compounds in coffee, such as antioxidants and anti-inflammatory agents, which may also play a role.

Caffeic acid, for example, is a polyphenol (antioxidant) found in coffee, and research suggests that these may be associated with improved cognitive function.

Courtesy – Deccan Herald                       

 

Taking low-dose aspirin every day may reduce the risk of a heart attack, prevent some cancers and extend lives over the course of 20 years in adults at high risk of heart disease, a new study has claimed.

Cardiovascular disease is the leading cause of death in both men and women, researchers said.

Aspirin can help patients at risk of heart disease because it thins the blood and prevents clotting. "Although the health benefits of aspirin are well established, few people take it," said lead author David B Agus from University of Southern California in the US.

"Our study shows multiple health benefits and a reduction in health care spending from this simple, low-cost measure that should be considered a standard part of care for the appropriate patient," said Agus.

Researchers used representative data from several surveys. To assess the long-term benefits of aspirin, they ran two scenarios which project the health of older Americans and their trajectory in ageing.

The model accounted for individual health characteristics such as chronic disease, the ability to conduct daily activities, body mass index and mortality, researchers said.

The first scenario in study, the "Guideline Adherence", focused on determining the potential health and savings, benefits and drawbacks of following the task force's guidelines from 2009.

The second scenario, "Universal Eligibility", was not realistic and aimed to measure the full potential benefits and drawbacks if all Americans 51 and older, regardless of the guidelines, took aspirin every day.

They found that following the guidelines would prevent 11 cases of heart disease and four cases of cancer for every 1,000 Americans aged 51 to 79.

Life expectancy would improve by 0.3 years (largely disability-free), so out of 1,000 people, eight more would reach age 80 and three more would reach the age of 100.

Also, by 2036, an estimated 900,000 more Americans would be alive as a result of the aspirin regimen, researchers said.

However, the researchers found no significant reduction for stroke incidence. Also, the rate of gastrointestinal bleeding would increase 25 per cent from the current rate.
This means that two out of 63 Americans could expect to suffer a bleeding incident between the ages of 51 to 79.

The optimistic "Universal Eligibility" scenario, which assumes that the clinically-proven benefits of aspirin extend to all older Americans, showed slightly larger health benefits than the "Guideline Adherence" scenario.

Although longer life spans mean an increase in lifetime medical costs, "observing the guidelines would yield positive and significant net value," researchers said. The study was published in the journal PLOS ONE.

Courtesy – Deccan Herald                       

 

In order to restrict the spread of diseases such as Zika and dengue, researchers have developed a platform that can analyse clinical samples from patients to diagnose infection by 416 viruses found in the world's tropical regions.

In addition to the pathogens, the platform detects others that as yet have been identified only sporadically but could become epidemics.

Examples include Mayaro, an alphavirus related to chikungunya that is transmitted by wild mosquitoes such as Haemagogus janthinomys.

"The number of patients with suspected dengue, Zika or chikungunya infection will increase when summer arrives," said Victor Hugo Aquino, professor at the University of Sao Paulo (USP) in Brazil.

"Conventional methods are frequently unable to confirm diagnosis of these diseases, so we don't know which viruses are circulating," said Aquino.

In his view, if a tool like this had been available when Zika began circulating in Brazil, it might have been possible to restrict its spread to the initial outbreak location.

"We took a long time to realise an epidemic was under way because no one was thinking of Zika at the time," he said.

"There are several other viruses that have not yet caused problems in humans but may do so one day," Aquino said.

"They are evolving all the time, and with the degradation of natural environments infectious agents once confined to natural niches could spread farther afield," added Aquino.

Although the platform is designed above all to detect pathogens transmitted by arthropods such as mosquitoes and ticks, it can also diagnose infectious agents transmitted by small mammals, like hantavirus.

Aquino explained that the selection encompasses all viruses occurring in tropical regions with DNA sequences deposited in GenBank, a public database maintained by the National Center for Biotechnology Information (NCBI), which is part of the US National Library of Medicine (NLM).

The platform consists of a DNA microarray slide with eight identical sub-arrays containing viral probes replicated at least three times to complete the array with 15,000 probes.

Each probe contains the sequences for 60 nucleotides that are complementary to the genomes of the viruses to be detected.

According to Aquino, the sequences were mounted on the basis of information from GenBank using bioinformatics.

"If a blood sample contains one of the 416 viruses included on the microchip, the pathogen's genome will bind with one of the probes to produce a marker that can be detected by a scanner," Aquino said.

The device that reads the results is the same as that used in microarray assays for the analysis of gene expression.

The validation tests do not point to cross-hybridisation, which produces a positive result for more than one infectious agent and hinders correct identification of single viruses.

The study was published in PLoS Neglected Tropical Diseases.

Courtesy – Deccan Herald                       

 

Children delivered by cesarean section have 40 per cent greater odds of becoming overweight or obese in childhood compared to those born vaginally, according to a new research. This association was even greater if their mother was overweight or obese, suggesting that among obese mothers vaginal delivery may help reduce the intergenerational association of obesity, according to researchers at Johns Hopkins University in the US.

This finding held even after accounting for the mother's age at the time of delivery, race, education, pre-pregnancy body mass index, pregnancy weight gain, air pollution exposure and the child's birth weight.

The researchers noted that having an overweight mother is often associated with overweight or obese children, regardless of how the child is born, but the effect was stronger among women who delivered through cesarean section. "We think that the reason for the difference may be due to the beneficial microbes found in the birth canal that newborns are exposed to during a vaginal birth," said lead author Noel Mueller, assistant professor at Johns Hopkins University.

"We suspect that these microbes may benefit a child's health, including enhancing metabolism and training the immune system," said Mueller. Researchers analysed data on 1,441 full-term deliveries from the Boston Birth Cohort.

Among the study group, 57 per cent of the women who gave birth by Cesarean were obese, and 53 per cent of those who delivered vaginally were obese. Children ranged from ages two to eight at the time of outcome measurement.

Courtesy – Deccan Herald

In a finding that could lead to better fuel cells and clean energy technologies, scientists have discovered that squeezing a platinum catalyst a fraction of a nanometre nearly doubles its activity.

A nanosize squeeze can significantly boost the performance of platinum catalysts that help generate energy in fuel cells, according to scientists at Stanford University in the US.
The team bonded a platinum catalyst to a thin material that expands and contracts as electrons move in and out, and found that squeezing the platinum a fraction of a nanometre nearly doubled its catalytic activity.

"In this study, we present a new way to fine-tune metal catalysts at the atomic scale," said Haotian Wang, a former graduate student at Stanford now at Harvard University.

"We found that ordinary battery materials can be used to control the activity of platinum and possibly for many other metal catalysts," said Wang.

The new technique can be applied to a wide range of clean technologies, Wang said, including fuel cells that use platinum catalysts to generate energy, and platinum electrolyzers that split water into oxygen and hydrogen fuel.

"Our tuning technique could make fuel cells more energy efficient and increase their power output," said Yi Cui, a professor of materials science and engineering at Stanford.
"It could also improve the hydrogen-generation efficiency of water splitters and enhance the production of other fuels and chemicals," said Cui.

Catalysts are used to make chemical reactions go faster while consuming less energy. The performance of a metal catalyst depends on its electronic structure - that is, how the electrons orbiting individual atoms are arranged.

The study focused on lithium cobalt oxide, a material widely used in batteries for cellphones and other electronic devices. The researchers stacked several layers of lithium cobalt oxide together to form a battery-like electrode.

"Applying electricity removes lithium ions from the electrode, causing it to expand by 0.01 nanometre. When lithium is reinserted during the discharge phase, the electrode contracts to its original size," Cui said.

For the experiment, the team added several layers of platinum to the lithium cobalt oxide electrode.

"Because platinum is bonded to the edge, it expands with the rest of the electrode when electricity is added and contracts during discharge," Cui said.

Separating the platinum layers a distance of 0.01 nanometre, or five per cent, had a significant impact on performance, Wang said.

"We found that compression makes platinum much more active. We observed a 90 per cent enhancement in the ability of platinum to reduce oxygen in water. This could improve the efficiency of hydrogen fuel cells," he said. The findings were published in the journal Science.

Courtesy – Deccan Herald

India is third among countries with the largest pictorial warning on tobacco products, according to a report released today.

The report said that India has moved to the third position out of 205 countries from its earlier ranking of 136 in 2014 and 123 in 2012.

"Nepal now has the largest warning requirements in the world at 90 per cent of the package front and back.

Vanuatu will implement 90 per cent pictorial warnings in 2017.
"India and Thailand are tied for third, requiring 85 per cent pictorial warnings.
In the 2014 report, Thailand was top ranked at 85 per cent," the report said.

The Cigarette Package Health Warnings International Status Report was released today by Canadian Cancer Society at the 7th session of the Conference of the Parties to the WHO Framework Convention on Tobacco Control (FCTC), being held at Greater Noida.

The report ranks 205 countries and territories on the size of their health warnings on cigarette packages and lists countries and territories that require graphic picture warnings.

The report shows a significant global momentum towards plain packaging with 4 countries requiring plain packs and 14 working on it.

The report also shows that 105 countries and territories have required picture health warnings on cigarette packages.

"By implementing 85 per cent pictorial health warnings front and back on all tobacco packages, Indian Government has set up an example for making India a global leader and sending a strong message to the global community about India's commitment to reducing tobacco use and the sickness and poverty it causes", said Bhavna B Mukhopadhyay, Chief Executive, Voluntary Health Association of India.

While inaugurating the COP7, Union Health Minister J P Nadda had said that 2016 has been a landmark year for tobacco control activities in India.

"We have successfully implemented, from April 2016, the large pictorial health warnings occupying 85 per cent of the principal display area of tobacco packs and on all forms of tobacco," he had said.

Courtesy – Deccan Herald

People who sleep five or fewer hours a night are likely to drink significantly more sugary caffeinated beverages, such as sodas and energy drinks, according to a new study.

"We think there may be a positive feedback loop where sugary drinks and sleep loss reinforce one another, making it harder for people to eliminate their unhealthy sugar habit," said lead author Aric A Prather, assistant professor at University of California, San Francisco (UCSF) in the US.

"This data suggests that improving people's sleep could potentially help them break out of the cycle and cut down on their sugar intake, which we know to be linked to metabolic disease," said Prather.

A growing body of research has linked sugary beverage consumption to metabolic syndrome, a cluster of conditions including high blood sugar and excess body fat, which can lead to obesity and type 2 diabetes.

Lack of sleep is also associated with a higher risk for metabolic disease.
Recently, several studies have linked the two factors in school-age children, showing that children who get less sleep are more likely to drink soda and other sugary beverages during the day, said Prather.

To understand whether this is a more general pattern in the adult population, Prather and his team analysed the 2005-2012 records of 18,779 participants in the US National Health and Nutrition Survey (NHANES).

The researchers found that people who regularly slept five or fewer hours per night also drank 21 per cent more caffeinated sugar-sweetened beverages - including both sodas and non-carbonated energy drinks - than those who slept seven to eight hours a night.

People who slept six hours per night regularly consumed 11 per cent more caffeinated sugar-sweetened beverages. On the other hand, the team found no association between sleep duration and consumption of juice, tea or diet drinks.

Prather noted that previous research has strongly indicated that sleep deprivation increases hunger, particularly hunger for sugary and fatty foods.

"Short sleepers may seek out caffeinated sugar-sweetened beverages to increase alertness and stave off daytime sleepiness," he said.

"However, it is not clear whether drinking such beverages affects sleep patterns, or if people who do not sleep much are more driven to consume them. Unfortunately, the data in the current study do not allow us to draw any conclusions about cause and effect," he added. The study appears in the journal Sleep Health.

Courtesy – Deccan Herald

Higher levels of iron in pregnant women may lead to an increased risk of gestational diabetes, a new study has warned.

The study by researchers from US National Institutes of Health (NIH) also raises questions about routine recommendations on iron supplementation in pregnancy.

Iron is regarded as a double-edged sword in living systems, as both its deficiency and excess can be harmful, researchers said.

While many guidelines recommend screening and treatment only as necessary for iron deficiency, several other groups such as the World Health Organisation (WHO recommend routine iron supplementation among pregnant women.

Emerging evidence has pointed to a possible link between higher iron stores and abnormal blood sugar control (including type 2 diabetes) in non-pregnant individuals.
Researchers did a case-control study of 107 gestational diabetes (GDM) cases and 214 controls (matched on age, gestational week of blood collection and race/ethnicity).

They looked at several biomarkers of iron status, including plasma hepcidin, ferritin, and soluble transferrin receptor (sTfR), and these data were used to calculate the sTfR:ferritin ratio, which captures both cellular iron need and availability of body iron stores.

These markers were longitudinally measured or calculated four times during pregnancy, twice before GDM diagnosis (gestational weeks 10-14 and 15-26), and twice afterwards (gestational weeks 23-31 and 33-39).

GDM diagnosis was ascertained from medical records based on oral glucose tolerance test results.

Statistical modelling was then used to calculate the odds ratio of GDM with iron status, accounting for factors such as demographics, pre-pregnancy body mass index (BMI), and other major risk factors.

Researchers found that for both hepcidin and ferritin, in the second trimester of pregnancy, those in the top 25 per cent of levels of these markers had around a 2.5 times increased subsequent risk of developing GDM compared with those in the bottom 25 per cent.

Similar findings were observed for ferritin levels in the first trimester. Describing the findings as biologically plausible, researchers offer various potential explanations.

Iron may play a role in the development of GDM through several potential mechanisms. As a strong pro-oxidant, free iron can promote several cellular reactions that generate reactive oxygen species and increase the level of oxidative stress.

Oxidative stress induced from excess iron accumulation can cause damage to and death of pancreatic beta cells which produce insulin and consequently, contribute to impaired insulin synthesis and secretion.The study was published in the journal Diabetologia.

Courtesy – Deccan Herald

More than half of India's area is "vulnerable" to earthquakes and several of its cities are at "high risk", a catastrophe risk management firm said today and advised "closing" these gaps. Speaking ahead of three-day Asian Ministerial Conference on Disaster Risk Reduction beginning tomorrow, the firm, in a statement, said that high quality and high resolution risk models are a "key" first step in helping drive the expansion of catastrophe insurance. "More than half of India by area is vulnerable to earthquakes and almost forty cities are particularly at risk. The rapid expansion in population and development in India is moving too fast to ensure adequate standards of protection," Robert Muir-Wood, chief research officer of the firm RMS, said, according to a statement. Muir-Wood noted that India has the highest number of people exposed to flood risk of any country worldwide, and the fastest increase in flood risk from development and climate change. He said the widespread damage from earthquake to ordinary buildings as seen in Nepal, after massive quake hit the Himalayan country last year, "could equally be the outcome in many cities in India." Referring to events such as 2001 Gujarat earthquake, 2005 Mumbai floods and inundation in Chennai last year, Muir-Wood added, "...the protection gap in India must be closed." Courtesy – Deccan Herald
Thursday, 03 November 2016 16:51

Lack of sleep may make you eat more calories

Written by

Sleep deprivation may make you munch on more calories the following day, potentially leading to weight gain and obesity, a new study has found.

The study found that sleep-deprived people consumed an average of 385 kilocalories per day extra, which is equivalent to the calories of about four and a half slices of bread.

The study, led by researchers at King's College London, combined the results of 11 studies with a total of 172 participants.

The analysis included studies that compared a partial sleep restriction intervention with an unrestricted sleep control and measured the individuals' energy intake over the next 24 hours.

They found partial sleep deprivation did not have a significant effect on how much energy people expended in the subsequent 24 hours. Therefore, participants had a net energy gain of 385 calories per day.

The researchers also found there was a small shift in what sleep deprived people ate - they had higher fat and lower protein intakes, but no change in carbohydrate intake.

"The main cause of obesity is an imbalance between calorie intake and expenditure and this study adds to accumulating evidence that sleep deprivation could contribute to this imbalance," said Gerda Pot, from King's College London.

"So there may be some truth in the saying 'early to bed, early to rise, makes a man healthy and wise'," Pot said.

"This study found that partial sleep deprivation resulted in a large net increased energy intake of 385 kcal per day," she said.

"If long-term sleep deprivation continues to result in an increased calorie intake of this magnitude, it may contribute to weight gain," she added.

"Our results highlight sleep as a potential third factor, in addition to diet and exercise, to target weight gain more effectively," Haya Al Khatib, PhD candidate at King's College London.

The study was published in the European Journal of Clinical Nutrition. 

Courtesy – Deccan Herald

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